开心散胶囊的质量标准研究文献综述

开心散有效成分及应用的研究进展

摘 要：开心散由人参、远志、菖蒲、茯苓四味中药组成，善治好忘，具宁心安神、健脾益智之功效。主要的活性成分有人参皂苷、远志皂苷、寡糖酯、细辛醚、茯苓酸、茯苓多糖等。研究表明，开心散具有抗抑郁、抗痴呆、改善学习记忆、抗疲劳等作用。本文通过检索近年来国内外有关开心散的文献，对开心散中各成分的活性成分、作用机制研究及现代应用进行总结归纳。

关键词：开心散；有效成分；机制；现代应用

Research progress on active ingredients and application of kaixinsan

Hu Yun Nanjing university of traditional Chinese medicine

Abstract: Kaixinsan is an ancient Chinese herbal decoction composed of Radix and Rhizome Ginseng, Radix Polygalae, Rhizoma Acori Tatarinowii and Poria. The Radix and Rhizome Ginseng-derived ginsenosides include Rb1, Rd, Re, Rg1, the Radix Polygalae-derived 3, 6-disinapoyl sucrose, the Rhizoma Acori Tatarinowii-derived alpha;-andbeta;-asarone and the Poria-derived pachymic acid.The study shows that kaixinsan has the effects of anti-depression, anti-dementia, improving learning and memory, anti-fatigue and so on. In this paper, the active ingredients, mechanism of action and modern application of each component in kaixinsan were summarized by searching the literature about kaixinsan in recent years.

Key words: Kaixinsan; active ingredients; mechanism; modern applications

开心散源自《备急千金要方》，由唐朝孙思邈编录整理。由人参、远志各四分，茯苓二两，石菖蒲一两组成，临床上对于抑郁症和阿尔兹海默症的治疗有很好的疗效。主治喜忘其前言，焦虑惊恐不安，精神恍惚，健忘痴呆等症状，为安神健智的基础方剂。该方始载于《千金要方卷十四》，其中远志、茯苓、菖蒲、人参是在中医书籍中治疗健忘证使用频率相对较高的药物。开心散作为传统复方，经临床和实验研究表明开心散停药后无延迟毒性作用，总体是安全、有效的^[1]。